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KMID : 0191120080230030514
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Journal of Korean Medical Science
2008 Volume.23 No. 3 p.514 ~ p.520
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Mechanism of Humoral and Cellular Immune Modulation Provided by Porcine Sertoli Cells
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Lee Hak-Mo
Oh Byoung-Chol
Lim Dong-Pyo
Lee Dong-Seup
Lim Hong-Gook
Park Cheon-Su
Lee Jeong-Ryul
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Abstract
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The understanding of main mechanisms that determine the ability of immune privilege
related to Sertoli cells (SCs) will provide clues for promoting a local tolerogenic
environment. In this study, we evaluated the property of humoral and cellular immune
response modulation provided by porcine SCs. Porcine SCs were resistant to human
antibody and complement-mediated formation of the membrane attack complex
(38.41±2.77% vs. 55.02±5.44%, p=0.027) and cell lysis (42.95±1.75% vs. 87.99
±2.25%, p<0.001) compared to immortalized aortic endothelial cells, suggesting
that porcine SCs are able to escape cellular lysis associated with complement activation
by producing one or more immunoprotective factors that may be capable of
inhibiting membrane attack complex formation. On the other hand, porcine SCs
and their culture supernatant suppressed the up-regulation of CD40 expression
(p<0.05) on DCs in the presence of LPS stimulation. These novel findings, as we
know, suggest that immune modulatory effects of porcine SCs in the presence of
other antigen can be obtained from the first step of antigen presentation. These
might open optimistic perspectives for the use of porcine SCs in tolerance induction
eliminating the need for chronic immunosuppressive drugs.
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KEYWORD
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Porcine Sertoli Cells, Immune Privilege, Humoral Immune Response, Cellular Immune Response, Tolerance
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